Nestled in downtown Louisville on historic West Main Street, along Museum Row, 21c Museum Hotel is a multi-venue contemporary art museum, an award-winning 91-room boutique hotel, and home to Proof on Main restaurant.21c Louisville engages visitors and locals alike with some of the world’s best contemporary art. Re-purposing the former home of a series of 19th-century warehouses, 21c Louisville reflects both its historical bones and its contemporary new life. With high ceilings and large windows, the spacious guests rooms at 21c Louisville were designed to feel like a residential respite from the thought-provoking art and activity that fills the museum galleries below.The Restorative Bed by Bryte is now available in the 21c Rooftop Apartment, offering a spacious one bedroom apartment with expansive rooftop garden overlooking the river and downtown Louisville. At every turn, 21c Louisville offers something to be curious about.